منابع مشابه
Clathrin-mediated endocytosis at synapses.
Neurons are communication specialists that convert electrical into chemical signals at specialized cell-cell junctions termed synapses. Arrival of an action potential triggers calcium-regulated exocytosis of neurotransmitter (NT) from small synaptic vesicles (SVs), which then diffuses across the synaptic cleft and binds to postsynaptic receptors to elicit specific changes within the postsynapti...
متن کاملRibbon synapses
Why are these synapses special? Because the electrical signals they transmit are not the same as those in other parts of the brain. Conventional synapses convey information arriving as a ‘pulse code’; action potentials lasting a few milliseconds trigger a transient burst of vesicle fusion and the amplitude of the action potential is fixed. But ribbon synapses transmit ‘analogue signals’, such a...
متن کاملModes of vesicle retrieval at ribbon synapses, calyx-type synapses, and small central synapses.
Introduction Endocytosis is essential for the maintenance of synaptic transmission because it recycles and thus prevents complete depletion of synaptic vesicles in the nerve terminal. The goal of understanding synaptic vesicle recycling mechanisms was launched in earnest in 1973 when John Heuser and Tom Reese published their landmark electron microscope images of synaptic terminals of the frog ...
متن کاملEndocytosis and vesicle recycling at a ribbon synapse.
At ribbon synapses, where exocytosis is regulated by graded depolarization, vesicles can fuse very rapidly with the plasma membrane (complete discharge of the releasable pool in approximately 200 msec). Vesicles are also retrieved very rapidly (time constant of approximately 1 sec), leading us to wonder whether their retrieval uses an unusual mechanism. To study this, we exposed isolated bipola...
متن کاملMunc13-independent vesicle priming at mouse photoreceptor ribbon synapses.
Munc13 proteins are essential regulators of exocytosis. In hippocampal glutamatergic neurons, the genetic deletion of Munc13s results in the complete loss of primed synaptic vesicles (SVs) in direct contact with the presynaptic active zone membrane, and in a total block of neurotransmitter release. Similarly drastic consequences of Munc13 loss are detectable in hippocampal and striatal GABAergi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Traffic
سال: 2007
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2007.00591.x